Endocrine Abstracts

Introduction: Ophthalmopathy, the most common extrathyroidal manifestation of Graves’ disease, occurs in 5% of cases in the absence of hyperthyroidism. Amiodarone, an iodine-rich antiarrhythmic drug, influences thyroid function, causing thyrotoxicosis or hypothyroidism, but its effect on thyroid autoimmunity is still a matter of debate.Case report: We report the case of a 58-year-old woman, suffering from non-sustained ventricular tachycardia, treat...

Introduction: Cushing’s syndrome (CS) is associated with central obesity, hypertension, insulin resistance, dyslipidemia, prothrombotic state, manifestations which form a metabolic syndrome. Accelerated vascular senescence, due to metabolic and vascular changes, increases, in CS, the cardiovascular risk and the mortality rates compared to age- and gender-matched population. On the other hand, obesity itself is associated with numerous comorbidities, including hypertension...

Background: Hyperthyroidismcan be associated withorbitopathy that manifests as exophtalmos due to orbital tissue inflammation. Usually the diagnosis is straight forward when an autoimmune thyroid disorder is present, but conditions mimicking Graves orbitopathy can pose a diagnostic challenge.Case report: We report the case of a 51 year old caucasian woman who was referred to our clinic with asymmetrical exophtalmos in november 2019. The patient stated th...

Background: Nowadays, primary hyperparathyroidism is usually diagnosed incidentally, in asymptomatic patients, while only around 15% of patients present the classical manifestations. Osteoclastoma, a benign bone lesion, is usually the late manifestation of hyperparathyroidism.Objective: We present the case of a 52 years old female (non-menopausal) recently diagnosed with ulnar osteoclastoma, primary hyperparathyroidism and secondary osteoporosis.<p c...

Introduction: Ipilimumab is an efficient medication used for the management of melanoma. However, it has been associated with endocrine dysfunctions such as hypophysitis, thyroid disorders (hypo- or hyperthyroidism), and adrenal insufficiency.Case report: We report the case of a 65-year-old male diagnosed with melanoma (Clark V). In 2022, he was operated and received treatment with ipilimumab 3 mg/kg. Three weeks after t...

Introduction: Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death ligand 1, and its ligand (PD-1/PD-L1) have become the current standard of care for many cancers. The mechanism of action of these drugs results in some new types of adverse events related to the immune system, most frequently involving the pituitary and thyroid glands.Case report: We present a case of mixed hypothyroidism (prim...

Background: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015-2017 with the aim to assess the incidence and impact of intraoperative features that may predispose to postoperative hypoparathyroidism (PoSH).Results: 171 (30.97%) pati...

Introduction: De Quervain’s thyroiditis, also known as subacute granulomatous thyroiditis, is a self-limiting inflammatory disorder of the thyroid gland. It is presumed to be caused by a viral infection and many patients have a history of an upper respiratory infection 2-8 weeks prior to the onset of thyroiditis. It is the most common cause for neck pain or discomfort, and it usually has a predictable course of thyroid function evolution. On ultrasonography the thyroid gl...

Introduction: Primary adrenal lymphoma is a rare cause of adrenal insufficiency, with most cases being of B-cell lymphoma.Case report: We present the case of a 51 yo man with a 1.5-month history of recurrent fever, nausea, vomiting, anorexia, weight loss of 12 kg, fatigue, polyarthalgia, hypotensive episodes (70/40 mmHg) and singultus. Before admission in our clinic he had a thoracic CT scan, which showed a 5.5 cm right adrenal mass and hyperplasia of th...

Introduction: Although patients with inflammatory bowel disease (IBD) -Crohn’s disease (CD) and ulcerative colitis (UC)- are considered prone to malnutrition, studies have shown an increased risk for obesity, especially visceral obesity and metabolic syndrome (MetS). Possible mechanisms involved include dysbiosis, gut microbiome and chronic inflammation. The aim of the study was to assess the prevalence of MetS and obesity in a group of IBD patients.<p class="abstext"...